Cardioprotective Effect of Acute Exercise in Breast Cancer Patients

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Cardiotoxicity is one of the most significant adverse effects in breast cancer patients treated with anthracyclines (a type of chemotherapy), so we propose to determine whether acute training (i.e., 24h before each chemotherapy session) could reduce the levels of a cardiac biomarker which measures muscle damage (NT-proBNP). Given the fact NT-proBNP attenuation has been observed with one session performed 24h before the first treatment, we propose to verify these findings in each cycle of doxorubicin analyzing how each type of exercise (aerobic, strength or combined aerobic + strength) may impact on anthracycline-induced cardiotoxicity, since this observation may be relevant considering the feasibility and low cost this implementation would represent in clinical practice.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
View:

• Woman with non-metastatic breast cancer not previously treated.

• Scheduled to receive neoadjuvant doxorubicin chemotherapy.

• Receive the oncologist´s approval for the practice of exercise.

• Acceptance of randomization.

• To sign an informed consent form before starting any measurement or procedure related to the project.

Locations
Other Locations
Spain
Ramón y Cajal Hospital
RECRUITING
Madrid
Contact Information
Primary
María Alonso
maria.alonsod@alumnos.upm.es
+ 34 678942096
Time Frame
Start Date: 2023-01-23
Estimated Completion Date: 2025-10
Participants
Target number of participants: 40
Treatments
Experimental: Exercise
Patients will perform an acute bout of exercise (different types of exercise for each cycle of anthracyclines) 24-48 hours prior to each cycle of anthracyclines.
No_intervention: Control
Patients will receive standard treatment for each type of tumor proposed by the hospital. This group of patients will be provided with the international recommendations on physical exercise for cancer patients.
Related Therapeutic Areas
Sponsors
Leads: Technical University of Madrid

This content was sourced from clinicaltrials.gov